Are you proud of working all night long and sleeping very little?

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Are you proud of working all night long and sleeping very little? Don’t you know that this destroys your brain! However, there is good news as well: your brain can be restored, and even if insomnia is forced, you can get your healthy sleep back.
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The brain is a unique universe where not everything is clear. In particular, we spend a third of our life sleeping, but it is clear that we really need it. Certain progress has already been made in the field of studying the phenomenon of sleep by scientists from the Polytechnic University (Italy) in collaboration with Giulio Tononi’s team from Wisconsin (USA). The international team is conducting new research to test the hypothesis that the brain needs sleep to form new neural connections. At the same time, the necessary volume is generated in the process of destroying old synaptic connections between cells, thus freeing up space for new contacts.
The team started researching the situation of “chronic sleep deprivation,” i.e. brain reactions to a state without sleep for several days. Three groups of mice were compared: sleep as usual, interruptions every 8 hours, and 4 days without sleep at all. After that, three-dimensional maps of synaptic (intercellular) connections and microglial tissue (microglia are an auxiliary tissue of nerve cells equal in number to neurons) of the brain of all three groups were studied using the method of electron microscopy.
Comparative analysis revealed that chronic sleep deprivation leads to a pronounced change in the work of astrocyte cells and microglia. Neurons are provided with everything necessary for their vital activity and metabolism through these elements, and these cells participate in the process of synaptic transmission and, in part, information processing. Acute and chronic sleep deprivation enhanced the phenomenon of astrocytic (by the name of the cell type) phagocytosis, which resulted in the destruction of entire cells or cell elements (synapses) by other cells. It was suggested that phagocytosis, which actually means that the brain is eating up its own cells, is a protective mechanism of the nervous system in response to long periods of wakefulness accompanied by the inevitable depletion of the synaptic activity of neurons and accessory glial cells. As such, the brain purges those elements of its network that have exhausted their life span.
Microglia examination under a microscope revealed that microglial cells were particularly highly active in mice that were chronically deprived of sleep, while phagocytosis significantly increased. Even a slight restriction in sleep led to microglial activation and an abnormal level of phagocytosis, where the strongest synaptic connections suffered. It is believed that the detected microglial activation may be a trigger factor in the development of neurological diseases in people with chronic sleep disorders, such as acquired (senile) dementia, Alzheimer’s disease, and Pick’s disease.
The first stage of the research revealed a high correlation between phagocytic activity of brain cells and sleep restriction but still failed to answer the main question of the research. The next stage should find out the restorative mechanisms in the nervous system that provide an understanding of the processes of memory consolidation in the normal sleep mode that are necessary for the long-term storage of information by the brain.
It turns out that sometimes “biohacking” means more sleep, better meals and less worries. But if this is impossible for some reason, the tests performed reveal that the #BasisNeuro neural stimulator is able to restore neuron activity to the optimal level and will ensure the prevention of mental disorders.
Site: www.ico.basisneuro.com
www.jneurosci.org/content/37/21/5263